•Physical–Chemical Properties (PCP)-motifs specific for allergens within a protein family were defined for 17 families.•PCP-motif scores distinguished allergenic sequences from 80,000 randomly selected non-allergenic sequences.•The motif scores within the Bet v 1 family correlated better than global sequence similarities with clinically observed cross-reactivities.•Several of the allergen-specific motifs coincide with experimentally determined IgE epitopes of allergenic profilins.•The PCP motifs discriminated sequences from allergenic pectate lyases from other pectate lyases in the human microbiome.
Molecular Immunology – Elsevier
Published: Jul 1, 2018
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