Distinguishing allergens from non-allergenic homologues using Physical–Chemical Property (PCP) motifs

Distinguishing allergens from non-allergenic homologues using Physical–Chemical Property (PCP)... •Physical–Chemical Properties (PCP)-motifs specific for allergens within a protein family were defined for 17 families.•PCP-motif scores distinguished allergenic sequences from 80,000 randomly selected non-allergenic sequences.•The motif scores within the Bet v 1 family correlated better than global sequence similarities with clinically observed cross-reactivities.•Several of the allergen-specific motifs coincide with experimentally determined IgE epitopes of allergenic profilins.•The PCP motifs discriminated sequences from allergenic pectate lyases from other pectate lyases in the human microbiome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Distinguishing allergens from non-allergenic homologues using Physical–Chemical Property (PCP) motifs

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.03.022
Publisher site
See Article on Publisher Site

Abstract

•Physical–Chemical Properties (PCP)-motifs specific for allergens within a protein family were defined for 17 families.•PCP-motif scores distinguished allergenic sequences from 80,000 randomly selected non-allergenic sequences.•The motif scores within the Bet v 1 family correlated better than global sequence similarities with clinically observed cross-reactivities.•Several of the allergen-specific motifs coincide with experimentally determined IgE epitopes of allergenic profilins.•The PCP motifs discriminated sequences from allergenic pectate lyases from other pectate lyases in the human microbiome.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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