Available online at www.sciencedirect.com ScienceDirect Disseminated tumor cells and dormancy in prostate cancer metastasis 1,2 1 Emma E van der Toom , James E Verdone 1,3,4,5 and Kenneth J Pienta It has been reported that disseminated tumor cells (DTCs) can developed disseminated disease remains a high priority be found in the majority of prostate cancer (PCa) patients, even for the ﬁeld. at the time of primary treatment with no clinical evidence of metastatic disease. This suggests that these cells escaped the Cancer can theoretically metastasize to almost every organ primary tumor early in the disease and exist in a dormant state of the body and these metastases play a central role in most in distant organs until they develop in some patients as overt cancer-related deaths. Tumor cells mainly travel to distant metastases. Understanding the mechanisms by which cancer sites through the blood. Important steps in haematogenous cells exit the primary tumor, survive the circulation, settle in a metastasis in solid tumors include migration and invasion distant organ, and exist in a quiescent state is critical to of those cells from the primary tumor into the blood vessels, understanding tumorigenesis, developing new prognostic circulation in the bloodstream (circulating tumor
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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