Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose... Bioorganic & Medicinal Chemistry 26 (2018) 2965–2972 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Discovery of a novel allosteric inhibitor scaffold for polyadenosine- diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 a,b,c,j d,j a,b d a,b Moses Moustakim , Kerstin Riedel , Marion Schuller , Andrè P. Gehring , Octovia P. Monteiro , e a,b f c a,g h,i Sarah P. Martin , Oleg Fedorov , Jag Heer , Darren J. Dixon , Jonathan M. Elkins , Stefan Knapp , d,⇑ a,b,⇑ Franz Bracher , Paul E. Brennan Structural Genomics Consortium, University of Oxford, ORCRB, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7DQ, UK Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7FZ, UK Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University, Munich 81377, Germany Charles River, Chesterford Research Park, CB10 1XL, UK UCB Pharma Ltd, Slough SL1 3WE, UK Structural Genomics Consortium, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, Campinas, SP 13083-886, Brazil Johann Wolfgang Goethe-University, Institute for PharmaceuticalChemistry and Buchmann Institute for Life Sciences, Frankfurt am Main 60438, Germany German http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Elsevier

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2

Loading next page...
 
/lp/elsevier/discovery-of-a-novel-allosteric-inhibitor-scaffold-for-polyadenosine-YiwqNFgxo0
Publisher
Elsevier
Copyright
Copyright © 2018 The Authors
ISSN
0968-0896
D.O.I.
10.1016/j.bmc.2018.03.020
Publisher site
See Article on Publisher Site

Abstract

Bioorganic & Medicinal Chemistry 26 (2018) 2965–2972 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Discovery of a novel allosteric inhibitor scaffold for polyadenosine- diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 a,b,c,j d,j a,b d a,b Moses Moustakim , Kerstin Riedel , Marion Schuller , Andrè P. Gehring , Octovia P. Monteiro , e a,b f c a,g h,i Sarah P. Martin , Oleg Fedorov , Jag Heer , Darren J. Dixon , Jonathan M. Elkins , Stefan Knapp , d,⇑ a,b,⇑ Franz Bracher , Paul E. Brennan Structural Genomics Consortium, University of Oxford, ORCRB, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7DQ, UK Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7FZ, UK Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University, Munich 81377, Germany Charles River, Chesterford Research Park, CB10 1XL, UK UCB Pharma Ltd, Slough SL1 3WE, UK Structural Genomics Consortium, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, Campinas, SP 13083-886, Brazil Johann Wolfgang Goethe-University, Institute for PharmaceuticalChemistry and Buchmann Institute for Life Sciences, Frankfurt am Main 60438, Germany German

Journal

Bioorganic & Medicinal ChemistryElsevier

Published: Jul 15, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off