Bioorganic & Medicinal Chemistry 26 (2018) 2965–2972 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Discovery of a novel allosteric inhibitor scaffold for polyadenosine- diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 a,b,c,j d,j a,b d a,b Moses Moustakim , Kerstin Riedel , Marion Schuller , Andrè P. Gehring , Octovia P. Monteiro , e a,b f c a,g h,i Sarah P. Martin , Oleg Fedorov , Jag Heer , Darren J. Dixon , Jonathan M. Elkins , Stefan Knapp , d,⇑ a,b,⇑ Franz Bracher , Paul E. Brennan Structural Genomics Consortium, University of Oxford, ORCRB, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7DQ, UK Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, Oxfordshire OX3 7FZ, UK Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University, Munich 81377, Germany Charles River, Chesterford Research Park, CB10 1XL, UK UCB Pharma Ltd, Slough SL1 3WE, UK Structural Genomics Consortium, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, Campinas, SP 13083-886, Brazil Johann Wolfgang Goethe-University, Institute for PharmaceuticalChemistry and Buchmann Institute for Life Sciences, Frankfurt am Main 60438, Germany German
Bioorganic & Medicinal Chemistry – Elsevier
Published: Jul 15, 2018
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