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in neurite elongation. Colchicine‐tubulin is a specific, substoichiometric poison of microtubule assembly. We have shown that colchicine‐tubulin does not cause existing PC12 microtubules to disassemble ...
Background: Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 ...
growth factor (NGF)-induced neurite outgrowth that occurs with a lag period of several days. During this lag period, increased synthesis or activation of assembly-promoting microtubule -associated proteins ...
-negative form of p160ROCK induced neurites in the presence of serum by inducing the reassembly of the intermediate filaments and microtubules . The neurite outgrowth by the p160ROCK inhibition was blocked ...
to disrupt existing dendrites previously induced by KCM. Agents known to cause microtubule disassembly (colchicine, nocodazole, or vinblastine) do not inhibit dendrite formation if added before or with KCM ...
neurite outgrowth and the number of branch points, a component of neurite outgrowth . In primed PC12 cells, following 24-h exposure, both CH3Hg and HgCl2 inhibited NGF-stimulated neurite outgrowth ...
not disassemble previously polymerized microtubules (not shown). However, as in the case of nocodazole or colchicine, it is likely that 2,4-D inhibits neurite extension by preventing microtubule assembly ...
neurons, the inhibitory effect of rotenone on the neurite outgrowth response of DA neurons was rescued by the RhoK inhibitor, Y27632 (Figs. 7H–J). FIG. 7. Open in new tabDownload slide Rotenone inhibits ...
previously reported to be involved in microtubule dynamics ( 23 , 24 ). Moreover, during differentiation, SCG10 enhances neurite outgrowth , a phenomenon that is believed to depend on microtubule dynamics ( 24 ...
Solomon F. ( 1980 ) Neuroblastoma cells recapitulate their detailed neurite morphologies after reversible microtubule disassembly . Cell 21 , 333 – 338 Google Scholar Crossref Search ADS PubMed WorldCat 48 ...
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