International Journal of Pharmaceutics 564 (2019) 10–21 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm Direct compaction properties of Zingiberis Rhizoma extracted powders coated with various shell materials: Improvements and mechanism analysis ⁎ ⁎ a,b a,b a,b, a a, b Zhe Li , Miaomiao Zhou , Fei Wu , Lan Shen , Xiao Lin , Yi Feng College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China ARTICLE INFO ABSTRACT Keywords: Direct compaction (DC) attracts more and more attention for tablet manufacturing; however, its application in Direct compaction natural plant product (NPP) tablets is still extremely limited. In this study, 8 kinds of composite particles (CPs) Natural plant product based on the Zingiberis Rhizoma extracted powder (ZR) (a natural plant product powder with poor DC properties) Composite particle were prepared with different shell materials, including hydroxypropyl methylcellulose (HPMC), poly- Flowability vinylpyrrolidone (PVP), dextran, inulin, mannitol, silica, and their combinations. Their physical properties and Compactibility compacting parameters were characterized comprehensively. The results demonstrated that (i) fluid bed coating
International Journal of Pharmaceutics – Elsevier
Published: Jun 10, 2019
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