Dimensionality reduction impedes the extraction of dynamic functional connectivity states from fMRI recordings of resting wakefulness

Dimensionality reduction impedes the extraction of dynamic functional connectivity states from... •Limitations and potential confounds of dimensionality reduction in extracting dFC states from fMRI recordings are evaluated.•It is shown that the decorrelating actions of principal component analysis can lead to spurious FC state dynamics.•This limitation is characterized by analyzing the composition and occupancy of FC states in positive and negative controls.•Accounting for this limitation, two interpretable FC states are extracted during resting wakefulness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Methods Elsevier

Dimensionality reduction impedes the extraction of dynamic functional connectivity states from fMRI recordings of resting wakefulness

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0165-0270
eISSN
1872-678X
D.O.I.
10.1016/j.jneumeth.2017.09.013
Publisher site
See Article on Publisher Site

Abstract

•Limitations and potential confounds of dimensionality reduction in extracting dFC states from fMRI recordings are evaluated.•It is shown that the decorrelating actions of principal component analysis can lead to spurious FC state dynamics.•This limitation is characterized by analyzing the composition and occupancy of FC states in positive and negative controls.•Accounting for this limitation, two interpretable FC states are extracted during resting wakefulness.

Journal

Journal of Neuroscience MethodsElsevier

Published: Jan 1, 2018

References

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