α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived suppressor cells

α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived... ObjectivesThe chemopreventive drug α-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. However, little is known about the effect of DFMO on the immune system of inflammatory arthritis. Here, we investigated the effect of DFMO in a well-established collagen-induced arthritis (CIA) mouse model and explored its effect on the immune system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Immunopharmacology Elsevier

α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived suppressor cells

International Immunopharmacology, Volume 71 – Jun 1, 2019

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Publisher
Elsevier
Copyright
Copyright © 2019 Elsevier B.V.
ISSN
1567-5769
eISSN
1878-1705
D.O.I.
10.1016/j.intimp.2019.03.040
Publisher site
See Article on Publisher Site

Abstract

ObjectivesThe chemopreventive drug α-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. However, little is known about the effect of DFMO on the immune system of inflammatory arthritis. Here, we investigated the effect of DFMO in a well-established collagen-induced arthritis (CIA) mouse model and explored its effect on the immune system.

Journal

International ImmunopharmacologyElsevier

Published: Jun 1, 2019

References

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