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correlated with more swollen astrocytes immunophenotyped by aquaporin‐4 (AQP4), glial fibrillary acidic protein (GFAP), and glutamate transporter ‐1 (GLT‐1). Low FA was also related to the loss of neurons ...
Abstract In the adult nervous system, glutamatergic neurotransmission is tightly controlled by neuron –glia interactions through glial glutamate reuptake by the specific transporters GLT-1 and GLAST ...
. The pathophysiological changes contributing to neuronal injury and perturbation of glial function in ALS are complex and effective therapeutic approaches are likely to require targeting of multiple effectors ...
PurposeStudies of neuronal development in the retina often examine the stages of proliferation, differentiation , and synaptic development, albeit independently. Our goal was to determine if a known ...
pathways are shown. Also notice that the direct GABAA receptor-mediated effects of GABA on GnRH neurons can be excitatory. VGLUT, Vesicular glutamate transporters 1 and 2; VGAT, vesicular GABA transporter 1 ...
astrocytes overexpress GFAP and vimentin [6], the proteins that contribute to the formation of the glial scar [6], as well as S100β, nestin, glutamate -aspartate transporter , and glial glutamate transporter 1 ...
↵ Bianco F , Fumagalli M , Pravettoni E , D'Ambrosi N , Volonté C , Matteoli M , Abbracchio MP , Verderio C . Pathophysiological roles of extracellular nucleotides in glial cells: differential expression ...
., Chen K., Sheng Q., Featherstone D.E. ( 2007 ) Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo . J. Neurosci. , 27 , 111 – 123 . Google Scholar ...
accumulation of glutamate , that can lead to cell death. Therefore, we consider glutamate transport into the neuronal cells and its interactions with cellular metabolism that can promote harmful effects. Five ...
. Released glutamate in the cleft can be taken up by astrocytes or back to neurons using excitatory amino acid transporters (EAATs) or leak channels, thereby recycling the released neurotransmitter. https ...
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