The 5-HT 3 receptor antagonists, ondansetron, MDL 72222 and granisetron (0.01–1 μM), produced a concentration-dependent increase of K + -evoked ( 3 H )ACh efflux in slices from rat entorhinal cortex preloaded with ( 3 H )choline. Bicuculline and flumazenil, antagonists at different sites of the GABA A receptor, also enhanced ( 3 H )ACh efflux. While the ACh releasing effect of ondansetron was markedly potentiated, in a TTX-sensitive manner, by bicuculline, the effects of MDL 72222 and granisetron were not significantly modified. A qualitatively identical interaction was found by using flumazenil, a GABA A antagonist at the benzodiazepine recognition site, in combination with the 5-HT 3 receptor antagonists. The potentiation by the GABA A antagonists of ( 3 H )ACh efflux was also observed in a superfusion medium deficient in Cl − . The nonspecific K + -channel blockers TEA and Ba 2+ also increased K + -evoked ( 3 H )ACh efflux in this preparation but the releasing effect was not modified by bicuculline. The results support the functional interaction of ondansetron with GABAergic interneurons in the rat entorhinal cortex, GABA-independent mechanisms may however be involved in the regulation of cortical cholinergic function by other 5-HT 3 receptor antagonists.
Brain Research – Elsevier
Published: Aug 10, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera