Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing Chick Brain Stem

Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing... During development of the chick brain stem, cranial motor neuron subpopulations differentiate at distinct axial levels and extend their axons along specific pathways into the periphery. Differences in phenotype and axonal trajectory of these neuronal populations might be governed by the expression of different repertoires of transcription factors. In 2- to 7-day chick embryos, we find that genes of the LIM homeobox family are expressed differentially among cranial motor nuclei. Whereas Islet-1 is expressed by motor neurons of all cranial nerves, Islet-2 is expressed only in nuclei that contain somatic motor neurons and transiently in a specialized population of contralateral vestibuloacoustic efferent neurons. Lim-3 is expressed in the hypoglossal and accessory abducens nuclei only, and Lim-1 and Lim-2 are not expressed by cranial motor neurons. Our findings are consistent with a role of these transcription factors in determining neuronal phenotype and axonal pathfinding. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Neuroscience Elsevier

Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing Chick Brain Stem

Loading next page...
 
/lp/elsevier/differential-expression-of-lim-homeobox-genes-among-motor-neuron-J96Jy0rkfa
Publisher
Elsevier
Copyright
Copyright © 1996 Academic Press
ISSN
1044-7431
DOI
10.1006/mcne.1996.0061
Publisher site
See Article on Publisher Site

Abstract

During development of the chick brain stem, cranial motor neuron subpopulations differentiate at distinct axial levels and extend their axons along specific pathways into the periphery. Differences in phenotype and axonal trajectory of these neuronal populations might be governed by the expression of different repertoires of transcription factors. In 2- to 7-day chick embryos, we find that genes of the LIM homeobox family are expressed differentially among cranial motor nuclei. Whereas Islet-1 is expressed by motor neurons of all cranial nerves, Islet-2 is expressed only in nuclei that contain somatic motor neurons and transiently in a specialized population of contralateral vestibuloacoustic efferent neurons. Lim-3 is expressed in the hypoglossal and accessory abducens nuclei only, and Lim-1 and Lim-2 are not expressed by cranial motor neurons. Our findings are consistent with a role of these transcription factors in determining neuronal phenotype and axonal pathfinding.

Journal

Molecular and Cellular NeuroscienceElsevier

Published: Oct 1, 1996

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off