Differential effects of enterostatin, galanin and opioids on high-fat diet consumption

Differential effects of enterostatin, galanin and opioids on high-fat diet consumption Enterostatin, the activation peptide of pancreatic procolipase, suppresses high-fat diet consumption both centrally and peripherally. κ-opioid agonists are also known to stimulate fat intake. These experiments were conducted to determine if an opioidergic central pathway might mediate the effects of enterostatin and galanin on fat intake. Male Sprague-Dawley rats were adapted to a high-fat diet (56% energy) and were implanted with cannulae aimed at the lateral cerebral ventricle (LV) or third cerebral ventricle (3V). Injection of enterostatin (1 nmol, LV) suppressed high-fat diet consumption in fasted (20 h) rats. This inhibition of high-fat intake by enterostatin was attenuated by central injection of the specific κ-agonist U50488 (2.15, 21.5 and 215 nmol, LV) in a dose-dependent manner in fasted rats while only the highest dose of U50488 (215 nmol, LV) independently produced stimulation of high-fat diet consumption in sated rats. Galanin (0.1 nmol, 3V) induced consumption of high-fat diet in sated rats similar to that seen with U50488 and this stimulation was attenuated by peripheral injection of naloxone (1.0 mg/kg i.p.). We present a model which integrates the present data, as well as previous findings, in explaining a potential common opioid pathway modulating fat consumption. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Differential effects of enterostatin, galanin and opioids on high-fat diet consumption

Brain Research, Volume 702 (1) – Dec 8, 1995

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Science B.V. All rights resreved
ISSN
0006-8993
DOI
10.1016/0006-8993(95)00966-8
Publisher site
See Article on Publisher Site

Abstract

Enterostatin, the activation peptide of pancreatic procolipase, suppresses high-fat diet consumption both centrally and peripherally. κ-opioid agonists are also known to stimulate fat intake. These experiments were conducted to determine if an opioidergic central pathway might mediate the effects of enterostatin and galanin on fat intake. Male Sprague-Dawley rats were adapted to a high-fat diet (56% energy) and were implanted with cannulae aimed at the lateral cerebral ventricle (LV) or third cerebral ventricle (3V). Injection of enterostatin (1 nmol, LV) suppressed high-fat diet consumption in fasted (20 h) rats. This inhibition of high-fat intake by enterostatin was attenuated by central injection of the specific κ-agonist U50488 (2.15, 21.5 and 215 nmol, LV) in a dose-dependent manner in fasted rats while only the highest dose of U50488 (215 nmol, LV) independently produced stimulation of high-fat diet consumption in sated rats. Galanin (0.1 nmol, 3V) induced consumption of high-fat diet in sated rats similar to that seen with U50488 and this stimulation was attenuated by peripheral injection of naloxone (1.0 mg/kg i.p.). We present a model which integrates the present data, as well as previous findings, in explaining a potential common opioid pathway modulating fat consumption.

Journal

Brain ResearchElsevier

Published: Dec 8, 1995

References

  • Adrenalectomy of the obese Zucker rat: effects on the feeding response to enterostatin and specific mRNA levels
    Okada, S.; Onai, T.; Kilroy, G.; York, D.A.; Bray, G.A.
  • Differential inhibition of fat intake in two strains of rat by the peptide enterostatin
    Okada, S.; York, D.A.; Bray, G.A.; Mei, J.; Erlanson-Albertsson, C.
  • Effect of galanin on food intake in rats: involvement of lateral and ventromedial hypothalamic sites
    Schick, R.R.; Samsami, S.; Zimmermann, J.P.; Eberl, T.; Endres, C.; Schusdziarra, V.; Classen, M.

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