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expression that is dependent on mechanism of action. These mechanism‐specific transcript profiles can be used as the basis for predictive toxicology. Potential applications include prioritizing chemicals ...
aromatic hydrocarbons (PAHs) and a limited number of other chemicals including N-nitrosamines and nicotine was represented as potential developmental /reproductive toxicants as well as estrogen and androgen ...
effects due to environmentl endocrine disruptors in humans and crucial to understanding the biological attention on the need for predictive tools to select the most likel estrogenic effects of estrogens (19 ...
rodent model, multiple mechanisms have been identified that play a role in DES‐induced toxic effects . Although DES is a potent estrogen , it can be used as a model compound to predict the effects of other ...
, and to provide mechanistic information on chemical effects in human cells and small model organisms. First‐generation predictive models for prenatal developmental toxicity have revealed a complex web of biological ...
functions of estrogen in reproductive and developmental stages. A microarray technology is a very valuable method for the prediction of hormone-responsive activities in various gene expressions. Thus, we ...
). These findings suggest that gsdf expression might be a useful biomarker for predicting the potential effect of chemicals on gonadal differentiation. We examined the gsdf expression in Japanese medaka exposed ...
teratogenicity and embryonic developmental toxicity of chemicals are one of the most important adverse effects , as embryogenesis is highly sensitive to toxicant exposure. Further, congenital abnormalities ...
by long- versus short-acting estrogens greatly affect the risks associated with exposures; therefore, we sought to develop tools to predict the ability of chemicals to maintain estrogenic ...
showed neurotoxicity and both pesticides showed developmental effects in the zebrafish assays, although methidathion is not developmentally toxic in vivo. CONCLUSIONS ToxCast's predictions showed ...
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