Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity

Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1005–1010 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin- 4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kc isoform selective activity a,d b,d c,d a e M. Srinivas , Anup Singh Pathania , Priya Mahajan , Praveen K. Verma , Santosh S. Chobe , b,d c,d a,d a,d,⇑ Fayaz A. Malik , Amit Nargotra , Ram A. Vishwakarma , Sanghapal D. Sawant Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India Department of Chemistry, Loknete Vyankatrao Hiray Arts, Science and Commerce College, Nashik (M.S.), India article i nfo abstract Article history: A strategy for construction of medicinally important 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)- Received 9 November 2017 ones has been devised and presented here. The compounds have been synthesized using one-pot multi- Revised 5 February 2018 component strategy under microwave assisted conditions. Triazolyl-quinazolinone based D-ring modi- Accepted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.032
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1005–1010 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin- 4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kc isoform selective activity a,d b,d c,d a e M. Srinivas , Anup Singh Pathania , Priya Mahajan , Praveen K. Verma , Santosh S. Chobe , b,d c,d a,d a,d,⇑ Fayaz A. Malik , Amit Nargotra , Ram A. Vishwakarma , Sanghapal D. Sawant Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India Department of Chemistry, Loknete Vyankatrao Hiray Arts, Science and Commerce College, Nashik (M.S.), India article i nfo abstract Article history: A strategy for construction of medicinally important 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)- Received 9 November 2017 ones has been devised and presented here. The compounds have been synthesized using one-pot multi- Revised 5 February 2018 component strategy under microwave assisted conditions. Triazolyl-quinazolinone based D-ring modi- Accepted

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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