Contemporary Clinical Trials 68 (2018) 102–108 Contents lists available at ScienceDirect Contemporary Clinical Trials journal homepage: www.elsevier.com/locate/conclintrial Design and Rationale for the Veterans Aﬀairs “Cooperative Study Program 594 Comparative Eﬀectiveness in Gout: Allopurinol vs. Febuxostat” Trial a,b,1 a,b,1 a,b c d d Timilsina S. , Brittan K. , O'Dell J.R. , Brophy M. , Davis-Karim A. , Henrie A.M. , e a,b f g d h c Neogi T. , Newcomb J. , Palevsky P.M. , Pillinger M.H. , Pittman D. , Taylor T.H. ,WuH. , a,b, Mikuls T.R. VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States University of Nebraska Medical Center, Omaha, NE, United States Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Cooperative Study Program Coordinating Center, Boston, MA, United States VA Cooperative Study Program, Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, United States Boston University School of Medicine, Boston, MA, United States VA Pittsburgh Healthcare System, Pittsburgh, PA, United States New York University Langone Medical Center, New York, NY, United States White River Junction VA Hospital, White River Junction, VT, United States ARTIC L E I NF O ABSTRAC T Keywords: Background: Gout patients do not routinely achieve optimal outcomes related in part to
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