Design and Rationale for the Veterans Affairs “Cooperative Study Program 594 Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat” Trial

Design and Rationale for the Veterans Affairs “Cooperative Study Program 594 Comparative... BackgroundGout patients do not routinely achieve optimal outcomes related in part to suboptimal administration of urate lowering therapy (ULT) including first-line xanthine oxidase inhibitors allopurinol or febuxostat. Studies leading to the approval of febuxostat compared this agent to allopurinol in inappropriately low, fixed doses. We will compare allopurinol with febuxostat in gout using appropriately titrated doses of both agents and a “treat-to-target” strategy congruent with specialty guidelines. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contemporary Clinical Trials Elsevier

Design and Rationale for the Veterans Affairs “Cooperative Study Program 594 Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat” Trial

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1551-7144
eISSN
1559-2030
D.O.I.
10.1016/j.cct.2018.03.015
Publisher site
See Article on Publisher Site

Abstract

BackgroundGout patients do not routinely achieve optimal outcomes related in part to suboptimal administration of urate lowering therapy (ULT) including first-line xanthine oxidase inhibitors allopurinol or febuxostat. Studies leading to the approval of febuxostat compared this agent to allopurinol in inappropriately low, fixed doses. We will compare allopurinol with febuxostat in gout using appropriately titrated doses of both agents and a “treat-to-target” strategy congruent with specialty guidelines.

Journal

Contemporary Clinical TrialsElsevier

Published: May 1, 2018

References

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