Journal of Colloid and Interface Science 516 (2018) 332–341 Contents lists available at ScienceDirect Journal of Colloid and Interface Science journal homepage: www.elsevier.com/locate/jcis Regular Article Design and evaluation of galactosylated chitosan/graphene oxide nanoparticles as a drug delivery system a,⇑ b c a a a Chen Wang , Zhiqiang Zhang , Binbin Chen , Liuqiong Gu , Yuan Li , Shuwei Yu School of Pharmacy, Xiamen Medical College, Xiamen 361023, PR China Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China Department of Pharmacy, Xiamen Xianyue Hospital, 361012, PR China graphical a bstract ar ti c l e i nf o ab stra ct Article history: We investigated a novel drug delivery system comprising nanoparticles based on galactosylated chi- Received 21 November 2017 tosan/graphene oxide/doxorubicin (GC–GO–DOX) for the therapeutic treatment of cancer. The drug deliv- Revised 18 January 2018 ery system was synthesized by loading a drug sample with galactosylated chitosan (GC) on a graphene Accepted 19 January 2018 oxide (GO) carrier. The results showed that the drug loading capacity was as high as 1.08 mg/mg (drug Available online 31 January 2018 per polymer). The nanoparticles remained stable under physiological conditions, and the drug was released
Journal of Colloid and Interface Science – Elsevier
Published: Apr 15, 2018
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