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. In normal gerbils, the macrophage toxin liposome ‐ encapsulated clodronate depleted blood monocytes and decreased quinolinic acid levels in liver (85%), duodenum (33%), and spleen (51%) but not serum or brain ...
in vivo, and the potential for subsequent immune responses that may limit prolonged transgene expression. We hypothesized that the depletion of macrophages via systemic delivery of liposome - encapsulated ...
Objective. To determine whether systemic elimination of macrophages by means of clodronate ‐containing liposomes counteracts inflammation and joint destruction in rats with established adjuvant ...
by Pseudomonas pneumonia. Macrophages in liver and spleen were depleted by administering liposome encapsulated dichloromethylene diphosphonate ( clodronate ) intravenously 36 h before the instillation of Pseudomonas ...
SUMMARY Clodronate , encapsulated within small unilamellar vesicles (SUVc) will deplete hepatic macrophages after intravenous injection. Functional studies, using probes to evaluate hepatic Fc and C3b ...
Objectives. To investigate the efficacy of a single i.v. dose of clodronate encapsulated within small unilamellar vesicles in suppressing joint inflammation and the histological progression of rat ...
neutrophil depletion and liposome - encapsulated clodronate (LEC)-mediated systemic macrophage depletion on the inflammatory signs (thermal hyperalgesia, mechanical allodynia, oedema and fever) and measured ...
Klodronatın (LEC: Liposome Encapsulated deplete or reduce resident and systemic macrophages Clodronate ) periferik sinir hasarı sonrası dejenerasyon- population during the degeneration-regeneration ...
. These factors likely impeded the therapeutic potential of clodronate in WNE. Thus, while clodronate provides an excellent system to deplete macrophages in the body, it has larger and broader effects ...
. Liposome - encapsulated clodronate (LC) produces a selective and systemic depletion of phagocytic macrophages in vivo. To study the role of initial infiltrating macrophages in renal fibrosis, we compared ...
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