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) or phosphatidylinositol 3 ‐ kinase (PI3K) are known to mediate IGF‐1 cell proliferative signals through the activation of extracellular signal‐regulated kinase 1/2 (Erk 1/2) and Akt, respectively. In MCF‐7 cells, IGF‐1 ...
and electrophoretic mobility shift assays. The role of the C/EBP binding site in the induction of the GSTA2 gene was assessed by luciferase reporter-gene activity. The role of phosphatidylinositol 3 - kinase (PI3- kinase ...
on specific targets of the insulin signaling pathway, including insulin receptor substrate (IRS), phosphatidylinositol 3 - kinase (PI3-K), AKT, and the glucose transporter (GLUT4) on NIH/3T3 cell line by western ...
by the phosphatidylinositol - 3 - kinase (PI3K) inhibitor wortmannin. The mitogen-activated protein kinase (MEK) inhibitor PD98059, which can inhibit phosphorylation of ERK, did not show this ability.Discussion and conclusion: Our ...
of this gene in gliomagenesis (Kunapuli et al., 2003 ). These phenotypic changes have been associated with decreased expression of matrix metalloproteinase (MMP) genes through the phosphatidylinositol 3 ‐ kinase ...
stability in an E3 ligase, proteasome, and PTEN- phosphatidylinositol 3 - kinase -AKT- dependent manner . J Biol Chem 2014 ; 289 : 22785 – 97 . Google Scholar CrossRef Search ADS PubMed 25 Xu L , Yang T , Su S ...
membrane after activation of phosphatidylinositol 3 - kinase (PI3K) and is activated through phosphorylation by phosphoinositide- dependent kinases 1 and 2 (30, 31). AKT can directly phosphorylate several ...
definitive endoderm (DE) when phosphatidylinositol - 3 - kinase signaling is reduced. (A): Activin-like activities work in collaboration with LY 294002 to drive formation of DE. LY 294002- dependent SOX17 ...
, phosphoinositide 3 - kinase type I (PI3K) promotes the assembly and translocation of V-ATPase (Sautin et al., 2005). PI3K activated by influenza A virus also interacts with the E subunit of the V1 domain of V-ATPase ...
and phosphatidylinositol 3 - kinase (PI3-K) pathways. Either treating human MSC cultures with the MAPK/ERK kinase inhibitor PD98059 or transferring them to serum-free medium with insulin or IGF-I permits BMP- dependent ...
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