•Two rainbow trout cell lines demonstrated contrasting susceptibility to FV3.•RTG-2 (susceptible) died more quickly, produced more virus but could not complete apoptosis.•Type I interferons could not limit FV3 induced cell death and replication was not required for FV3 induced cytotoxicity.•FV3 demonstrated significantly higher entry rates in RTG-2 compared to the resistant cell line, RTgutGC.•FV3 is highly manipulative of the its host cell’s innate immune responses.
Virus Research – Elsevier
Published: Jun 15, 2017
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