Delineating the roles of cellular and innate antiviral immune parameters mediating ranavirus susceptibility using rainbow trout cell lines

Delineating the roles of cellular and innate antiviral immune parameters mediating ranavirus... •Two rainbow trout cell lines demonstrated contrasting susceptibility to FV3.•RTG-2 (susceptible) died more quickly, produced more virus but could not complete apoptosis.•Type I interferons could not limit FV3 induced cell death and replication was not required for FV3 induced cytotoxicity.•FV3 demonstrated significantly higher entry rates in RTG-2 compared to the resistant cell line, RTgutGC.•FV3 is highly manipulative of the its host cell’s innate immune responses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Delineating the roles of cellular and innate antiviral immune parameters mediating ranavirus susceptibility using rainbow trout cell lines

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2017.06.008
Publisher site
See Article on Publisher Site

Abstract

•Two rainbow trout cell lines demonstrated contrasting susceptibility to FV3.•RTG-2 (susceptible) died more quickly, produced more virus but could not complete apoptosis.•Type I interferons could not limit FV3 induced cell death and replication was not required for FV3 induced cytotoxicity.•FV3 demonstrated significantly higher entry rates in RTG-2 compared to the resistant cell line, RTgutGC.•FV3 is highly manipulative of the its host cell’s innate immune responses.

Journal

Virus ResearchElsevier

Published: Jun 15, 2017

References

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