Japanese medaka ( Oryzias latipes ) were continuously exposed to concentrations of 0, 2, 20, and 50 μg/L octylphenol, 0.01‰ dimethyl sulfoxide, and 100 ng/L 17 β -estradiol from 2 to 4 h postfertilization until maturity. Exposure to ≥2μg/L octylphenol caused a 20–30% increase in mortality both before and after hatch. Growth was significantly decreased in fish exposed to 50 μg/L octylphenol and in the positive control. Sex ratio changed from 42:58 (females:males) in controls to 57:40 at 50 μg/L octylphenol, and 3 and 4% of the medaka exposed to 50 μg/L octylphenol and 17 β -estradiol developed testes–ova. In cross-mating experiments, mating of exposed males with control females resulted in an up to 11% lower fertilization rate than in controls. Results indicate that continuous exposure to octylphenol causes a broad variety of reproductive effects, which can be correlated with the xenoestrogenic potential of octylphenol.
Ecotoxicology and Environmental Safety – Elsevier
Published: Mar 1, 2002
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