Death to flies: Drosophila as a model system to study programmed cell death

Death to flies: Drosophila as a model system to study programmed cell death Programmed cell death (PCD) is essential for the removal of unwanted cells and is critical for both restricting cell numbers and for tissue patterning during development. Components of the cell death machinery are remarkably conserved through evolution, from worms to mammals. Central to the PCD process is the family of cysteine proteases, known as caspases, which are activated by death-inducing signals. Comparisons between C. elegans and mammalian PCD have shown that there is additional complexity in the regulation of PCD in mammals. The fruitfly, Drosophila melanogaster , is proving an ideal genetically tractable model organism, of intermediary complexity between C. elegans and mammals, in which to study the intricacies of PCD. Here, we review the literature on PCD during Drosophila development, highlighting the methods used in these studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Immunological Methods Elsevier

Death to flies: Drosophila as a model system to study programmed cell death

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Ltd
ISSN
0022-1759
DOI
10.1016/S0022-1759(02)00068-6
Publisher site
See Article on Publisher Site

Abstract

Programmed cell death (PCD) is essential for the removal of unwanted cells and is critical for both restricting cell numbers and for tissue patterning during development. Components of the cell death machinery are remarkably conserved through evolution, from worms to mammals. Central to the PCD process is the family of cysteine proteases, known as caspases, which are activated by death-inducing signals. Comparisons between C. elegans and mammalian PCD have shown that there is additional complexity in the regulation of PCD in mammals. The fruitfly, Drosophila melanogaster , is proving an ideal genetically tractable model organism, of intermediary complexity between C. elegans and mammals, in which to study the intricacies of PCD. Here, we review the literature on PCD during Drosophila development, highlighting the methods used in these studies.

Journal

Journal of Immunological MethodsElsevier

Published: Jul 1, 2002

References

  • The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
    Brachmann, C.B.; Jassim, O.W.; Wachsmuth, B.D.; Cagan, R.L.
  • Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
    Chen, P.; Rodriguez, A.; Erskine, R.; Thach, T.; Abrams, J.M.
  • An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster
    Dalby, B.; Pereira, A.J.; Goldstein, L.S.
  • DRONC, an ecdysone inducible Drosophila caspase
    Dorstyn, L.; Colussi, P.A.; Quinn, L.M.; Richardson, H.; Kumar, S.
  • Interaction between the cellular and humoral immune response in Drosophila
    Elrod-Erickson, M.; Misra, S.; Schneider, D.
  • Programmed cell death in C. elegans
    Fraser, A.G.
  • Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE
    Fraser, A.G.; Evan, G.I.
  • drICE is an essential caspase required for apoptotic activity in Drosophila cells
    Fraser, A.G.; McCarthy, N.J.; Evan, G.I.
  • Induction of apoptosis by Drosophila reaper , hid and grim through inhibition of IAP function
    Goyal, L.; MacCall, K.; Agapite, J.; Hartwieg, E.; Steller, H.
  • Genetics: a touch of elegance with RNAi
    Hunter, C.P.
  • Gene silencing: shrinking the black box of RNAi
    Hunter, C.P.
  • The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
    Leulier, F.; Rodriguez, A.; Khush, R.S.; Abrams, J.M.; Lemaitre, B.
  • The Drosophila caspase DRONC is regulated by DIAP1
    Meier, P.; Silke, J.; Leevers, S.J.; Evan, G.I.
  • Activation of the reaper gene during ectopic cell killing in Drosophila
    Nordstrom, W.; Chen, P.; Steller, H.; Abrams, J.M.
  • Advances in fluorescence in situ hybridization
    Raap, A.K.
  • The inhibitor of apoptosis protein-binding domain of smac is not essential for its proapoptotic activity
    Roberts, D.L.; Merrison, W.; MacFarlane, M.; Cohen, G.M.
  • A targeted gene knockout in Drosophila
    Rong, Y.S.; Golic, K.G.
  • A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina
    Tanenbaum, S.B.; Gorski, S.M.; Rusconi, J.C.; Cagan, R.L.
  • Scythe: a novel reaper-binding apoptotic regulator
    Thress, K.; Henzel, W.; Shillinglaw, W.; Kornbluth, S.
  • Reaper-induced dissociation of a Scythe-sequestered cytochrome c -releasing activity
    Thress, K.; Evans, E.K.; Kornbluth, S.
  • The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
    Toba, G.; Ohsako, T.; Miyata, N.; Ohtsuka, T.; Seong, K.H.; Aigaki, T.
  • Preferential transposition of Drosophila P elements to nearby chromosomal sites
    Tower, J.; Karpen, G.H.; Craig, N.; Spradling, A.C.
  • Efficient and dispersed local P element transposition from Drosophila females
    Zhang, P.; Spradling, A.C.

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