Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines

Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant... Background & Aims Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) cytotoxicity in hepatocellular carcinoma cells is mediated by lysosomal permeabilization. Our aims were to determine which TRAIL receptor, death receptor (DR) 4 or DR5, mediates lysosomal permeabilization and assess whether receptor endocytosis followed by trafficking to lysosomes contributes in this process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gastroenterology Elsevier

Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines

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Publisher
Elsevier
Copyright
Copyright © 2009 AGA Institute
ISSN
0016-5085
eISSN
1528-0012
D.O.I.
10.1053/j.gastro.2009.02.071
Publisher site
See Article on Publisher Site

Abstract

Background & Aims Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) cytotoxicity in hepatocellular carcinoma cells is mediated by lysosomal permeabilization. Our aims were to determine which TRAIL receptor, death receptor (DR) 4 or DR5, mediates lysosomal permeabilization and assess whether receptor endocytosis followed by trafficking to lysosomes contributes in this process.

Journal

GastroenterologyElsevier

Published: Jun 1, 2009

References

  • cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis
    Guicciardi, M.E.; Bronk, S.F.; Werneburg, N.W.
  • Lysosomes in cell death
    Guicciardi, M.E.; Leist, M.; Gores, G.J.
  • The role of receptor internalization in CD95 signaling
    Lee, K.H.; Feig, C.; Tchikov, V.
  • Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
    Roberts, L.R.; Kurosawa, H.; Bronk, S.F.
  • Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment
    Press, B.; Feng, Y.; Hoflack, B.
  • Hepatocytes in the bile duct-ligated rat express Bcl-2
    Kurosawa, H.; Que, F.G.; Roberts, L.R.

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