[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice

[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve... •Oral delivery of MA-[D-Leu-4]-OB3 in dodecyl maltoside is feasible in DIO mice.•MA-[D-Leu-4]-OB3 improves glucose tolerance in DIO mice.•The effects of MA-[D-Leu-4]-OB3 on glycemic control are independent of its effects on energy balance.•MA-[D-Leu-4]-OB3 may slow the progression of prediabetes to overt diabetes in DIO mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2017.12.012
Publisher site
See Article on Publisher Site

Abstract

•Oral delivery of MA-[D-Leu-4]-OB3 in dodecyl maltoside is feasible in DIO mice.•MA-[D-Leu-4]-OB3 improves glucose tolerance in DIO mice.•The effects of MA-[D-Leu-4]-OB3 on glycemic control are independent of its effects on energy balance.•MA-[D-Leu-4]-OB3 may slow the progression of prediabetes to overt diabetes in DIO mice.

Journal

PeptidesElsevier

Published: Mar 1, 2018

References

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