Four new aristolane sesquiterpenes named nambinones A–C ( 1 – 3 ) and 1- epi -nambinone B ( 4 ), a new sesquiterpene, nambinone D ( 5 ), a known compound, aurisin A ( 6 ) as well as a new dimeric sesquiterpene, aurisin K ( 7 ), were isolated from two isolates of luminescent mushroom, Neonothopanus nambi , PW1 and PW2. These structures were established on the basis of spectroscopic evidence. The relative configuration of 6 was determined by X-ray crystallographic analysis. Compounds 6 and 7 exhibited antimalarial activity against Plasmodium falciparum and antimycobacterial activity against Mycobacterium tuberculosis . Compounds 3 , 6 , and 7 showed cytotoxicity against NCI-H187 cancer cell lines. In addition, 6 and 7 showed cytotoxicity against the cholangiocarcinoma cell lines.
Tetrahedron – Elsevier
Published: Sep 30, 2012
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