Cytokines and related receptor-mediated signaling pathways

Cytokines and related receptor-mediated signaling pathways Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, non-enzymatic glycoproteins whose actions are both diverse and overlapping (specificity/redundancy) and may affect diverse and overlapping target cell populations. In many instances, individual cytokines have multiple biological activities. Different cytokines can also have the same activity, which provides for functional redundancy within the inflammatory and immune systems. As biological cofactors that are released by specific cells, cytokines have specific effects on cell–cell interaction, communication, and behavior of other cells. As a result, it is infrequent that loss or neutralization of one cytokine will markedly interfere with either of these systems. The biological effect of one cytokine is often modified or augmented by another. Because an inter-digitating, redundant network of cytokines is involved in the production of most biological effects, both under physiologic and pathologic conditions, it usually requires more than a single defect in the network to alter drastically the outcome of the process. This fact therefore may have crucial significance in the development of therapeutic strategies for bio-pharmacologic intervention in cytokine-mediated inflammatory processes and infections. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

Cytokines and related receptor-mediated signaling pathways

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science (USA)
ISSN
0006-291x
DOI
10.1016/S0006-291X(02)02287-8
Publisher site
See Article on Publisher Site

Abstract

Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, non-enzymatic glycoproteins whose actions are both diverse and overlapping (specificity/redundancy) and may affect diverse and overlapping target cell populations. In many instances, individual cytokines have multiple biological activities. Different cytokines can also have the same activity, which provides for functional redundancy within the inflammatory and immune systems. As biological cofactors that are released by specific cells, cytokines have specific effects on cell–cell interaction, communication, and behavior of other cells. As a result, it is infrequent that loss or neutralization of one cytokine will markedly interfere with either of these systems. The biological effect of one cytokine is often modified or augmented by another. Because an inter-digitating, redundant network of cytokines is involved in the production of most biological effects, both under physiologic and pathologic conditions, it usually requires more than a single defect in the network to alter drastically the outcome of the process. This fact therefore may have crucial significance in the development of therapeutic strategies for bio-pharmacologic intervention in cytokine-mediated inflammatory processes and infections.

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Oct 4, 2002

References

  • Pro-inflammatory cytokines
    Dinarello, C.A
  • Regulation of cytokine gene transcription in the immune system
    Holloway, A.F; Rao, S; Shannon, M.F
  • Inflammation in the nervous system: the human perspective
    Bauer, J; Rauschka, H; Lassmann, H
  • Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
    Ulevitch, R.J; Tobias, P.S
  • How bacteria initiate inflammation: aspects of the emerging story
    Hersh, D; Weiss, J; Zychlinsky, A
  • Innate immunity and inflammation: a transcriptional paradigm
    Hawiger, J
  • Regulation of cytokine gene expression
    Taniguchi, T
  • Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function
    Raber, J; Sorg, O; Horn, T.F; Yu, N; Koob, G.F; Campbell, I.L; Bloom, F.E
  • Secretion capture and report web: use of affinity derivatized agarose microdroplets for the selection of hybridoma cells
    Gray, F; Kenney, J.S; Dunne, J.F
  • On the existence of cytokines in invertebrates
    Beschin, A; Bilej, M; Torreele, E; De Baetselier, P
  • Cell function-based flow cytometry
    Bleesing, J.J; Fleisher, T.A
  • Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: comparison of ELISPOT a novel ELISA and real-time RT-PCR
    Ekerfelt, C; Ernerudh, J; Jenmalm, M.C
  • The receptors for regulatory molecules in hematopoiesis
    Olsson, I; Gullberg, U; Lantz, M; Richter, J
  • Oxygen homeostasis, thiol equilibrium and redox regulation of signaling transcription factors in the alveolar epithelium
    Haddad, J.J
  • Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
    Haddad, J.J

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