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) and calreticulin [8], all of which are potentially antigenic, leading to the development of autoantibodies against each protein in either SLE or rheumatoid arthritis patients [9]. Why these carefully packaged ...
escalation design with almost identical eligibility criteria [2], and so were of use in interpreting potential idiosyncratic toxicities. The absence of cytokine release in HAVH autoantibody -positive subjects ...
. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen . Nature 1992 ; 358 : 155 – 7 . Google Scholar Crossref Search ADS PubMed WorldCat 16 Goebels N , Hofstetter H, Schmidt S et al ...
in many animal models [6–13]. Anti-glomerular basement membrane (GBM) glomerulonephritis (GN) and lupus GN are of an autoimmune nature [14, 15]. Generation of new autoantibodies to diverse autoantigens ...
In examining the potential proliferative response of i.p. cells, parallel control studies used spleen cells as responders co -cultured with irradiated autologous spleen cells. Under these conditions, splenocytes ...
responses to whole protein naturally processed by B cells. It is interesting to note that the immunodominant peptide found to activate T cell clones in the present work overlaps with a cryptic peptide ...
The concept that the main cause of inflammatory bowel disease (IBD) is immunologic in nature arose from observations of massive lymphocyte infiltrates (both B and T cells) in the mucosa along ...
abnormal co -stimulatory signals sustaining the production of pathogenic autoantibodies . Immunotherapy that specifically blocks the pathogenic T and B cell interaction in lupus can be developed based ...
] may not be detected by standard methods. More recently, cases of circulating but not deposited anti-GBM antibodies have been reported, potentially due to differences in expression of glomerular cryptic ...
are tantalising they fail to show whether such potentially cross-reactive epitopes are generated in vivo during natural infection. Finally, a recent study addressing changes in specificity of human anti-PDC ...
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