Cross- immunity of a H9N2 live attenuated influenza vaccine against H5N2 highly pathogenic avian influenza virus in chickens

Cross- immunity of a H9N2 live attenuated influenza vaccine against H5N2 highly pathogenic avian... •H9N2 LAIV provides cross protective immunity against H5N2 virus in chickens.•H9N2 LAIV activates H5N2 cross-reactive T cells and these T cells expand robustly following H5N2 exposure.•Passively transferred H9N2 LAIV anti-serum can effectively protect chickens against lethal H5N2 challenge.•Non-neutralizing NP-specific IgGs induced by H9N2 LAIV are of contributing roles for cross immunity against H5N2 virus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Microbiology Elsevier

Cross- immunity of a H9N2 live attenuated influenza vaccine against H5N2 highly pathogenic avian influenza virus in chickens

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0378-1135
eISSN
1873-2542
D.O.I.
10.1016/j.vetmic.2018.05.005
Publisher site
See Article on Publisher Site

Abstract

•H9N2 LAIV provides cross protective immunity against H5N2 virus in chickens.•H9N2 LAIV activates H5N2 cross-reactive T cells and these T cells expand robustly following H5N2 exposure.•Passively transferred H9N2 LAIV anti-serum can effectively protect chickens against lethal H5N2 challenge.•Non-neutralizing NP-specific IgGs induced by H9N2 LAIV are of contributing roles for cross immunity against H5N2 virus.

Journal

Veterinary MicrobiologyElsevier

Published: Jul 1, 2018

References

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