Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression Corticotropin-releasing factor (CRF) and its related family members are implicated in stress-related disorders such as anxiety and depression. Recently, two new members of this neuropeptide family have been discovered in the brain: urocortin II (also known as stresscopin-related peptide) and urocortin III (also known as stresscopin). These urocortins are selective agonists for the CRF 2 receptor, show a distinct neuroanatomical localization and are involved in stress-coping responses such as anxiolysis. Thus, CRF, the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Pharmacology Elsevier

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ireland Ltd
ISSN
1471-4892
DOI
10.1016/S1471-4892(01)00117-5
Publisher site
See Article on Publisher Site

Abstract

Corticotropin-releasing factor (CRF) and its related family members are implicated in stress-related disorders such as anxiety and depression. Recently, two new members of this neuropeptide family have been discovered in the brain: urocortin II (also known as stresscopin-related peptide) and urocortin III (also known as stresscopin). These urocortins are selective agonists for the CRF 2 receptor, show a distinct neuroanatomical localization and are involved in stress-coping responses such as anxiolysis. Thus, CRF, the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response.

Journal

Current Opinion in PharmacologyElsevier

Published: Feb 1, 2002

References

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