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animals. The nociceptive and anxiety -like behaviors, as well as phosphorylated extracellular signal-regulated kinases 1 / 2 and corticotropin - releasing factor receptors expression, were quantified ...
regions. Corticotropin - releasing factor (CRF) Type 1 and Type 2 receptors are distributed in the DRN. Both receptors have been implicated in regulating negative aspects including stress, fear, and anxiety ...
2345'5487 Decoding Corticotropin - Releasing Factor Receptor Type 1 Crystal Structures 1 1 2 1 3 Andrew S. Doré , Andrea Bortolato , Kaspar Hollenstein , Robert K.Y. Cheng , Randy J. Read and 1 ,* Fiona H ...
. Rationale: Hypersecretion of corticotropin releasing factor (CRF) has been implicated in both severe anxiety disorders and major depression. Although the role of the CRF1 receptor in the anxiogenic effects ...
of the corticotropin - releasing factor (CRF)–urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety . It has been proposed that CRF–CRF receptor type 1 (CRFR1 ...
The corticotropin releasing factors receptor - 1 and receptor - 2 (CRF1R and CRF2R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF1R have been developed ...
Corticotropin - releasing factor (CRF) and cholecystokinin (CCK), two highly colocalized neuropeptides, have been linked to the etiology of stress-related anxiety disorders. Recent evidence points ...
, anxiety and addictive disorders. Based on pharmacophore of the CRF1 receptor antagonists, a new series of thiazolo[4,5-d] pyrimidines were synthesized as Corticotropin - releasing factor (CRF) receptor ...
Corticotropin ‐ releasing factor (CRF) stimulates adrenocorticotropic hormone (ACTH) secretion from the pituitary gland and is an essential regulator of the hypothalamic–pituitary–adrenocortical axis ...
Corticotropin - releasing hormone 1,2 (Crh), a 41-residue polypeptide, activates two G-protein–coupled receptors , Crhr1 (refs 3–5) and Crhr2 (refs 6–9), causing (among other transductional events ...
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