Correlation between cardiovascular disease and diabetes mellitus: current concepts

Correlation between cardiovascular disease and diabetes mellitus: current concepts Individuals exhibiting precursor symptoms of diabetes mellitus or reaching diagnostic thresholds for diabetes are at increased risk of death due to cardiovascular disease (CVD). Moreover, patients with diabetes alone, as well as those who have diabetes paired with established CVD, remain undertreated for cardiovascular risk factors. The clear correlation between these disease processes has led many to speculate that they share common pathogenetic processes. Recent research has made it increasingly evident that the core metabolic defects that mark diabetes, including impaired glucose tolerance, insulin resistance, and proinflammatory and prothrombotic states, lead to endothelial dysfunction and accelerate atherogenesis. Moreover, increases in sympathetic tone with diabetes are associated with changes in cardiac and vascular function that lead to hypertension, left ventricular dysfunction, and cardiac autonomic neuropathy; such changes set the stage for arrhythmia, silent infarction, and sudden death. Furthermore, diabetes-related changes in metabolic and autonomic functioning, as well as increases in inflammatory and thrombotic signaling, compromise the ability of myocardial and vascular tissue to remodel after injury and to recover and sustain functionality. Because potentiation of atherogenesis and cardiac dysfunction occurs in the presence of early diabetic symptoms as well as in the established disease, early implementation of strategies to reduce cardiovascular risk factors and to slow diabetes progression may help to improve long-term outcomes for at-risk individuals. Such interventions may include well-established treatments for hypertension and dyslipidemia, diet improvements, weight loss, and exercise as well as novel pharmacologic interventions aimed at newly identified therapeutic targets. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Medicine Elsevier

Correlation between cardiovascular disease and diabetes mellitus: current concepts

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Abstract

Individuals exhibiting precursor symptoms of diabetes mellitus or reaching diagnostic thresholds for diabetes are at increased risk of death due to cardiovascular disease (CVD). Moreover, patients with diabetes alone, as well as those who have diabetes paired with established CVD, remain undertreated for cardiovascular risk factors. The clear correlation between these disease processes has led many to speculate that they share common pathogenetic processes. Recent research has made it increasingly evident that the core metabolic defects that mark diabetes, including impaired glucose tolerance, insulin resistance, and proinflammatory and prothrombotic states, lead to endothelial dysfunction and accelerate atherogenesis. Moreover, increases in sympathetic tone with diabetes are associated with changes in cardiac and vascular function that lead to hypertension, left ventricular dysfunction, and cardiac autonomic neuropathy; such changes set the stage for arrhythmia, silent infarction, and sudden death. Furthermore, diabetes-related changes in metabolic and autonomic functioning, as well as increases in inflammatory and thrombotic signaling, compromise the ability of myocardial and vascular tissue to remodel after injury and to recover and sustain functionality. Because potentiation of atherogenesis and cardiac dysfunction occurs in the presence of early diabetic symptoms as well as in the established disease, early implementation of strategies to reduce cardiovascular risk factors and to slow diabetes progression may help to improve long-term outcomes for at-risk individuals. Such interventions may include well-established treatments for hypertension and dyslipidemia, diet improvements, weight loss, and exercise as well as novel pharmacologic interventions aimed at newly identified therapeutic targets.

Journal

The American Journal of MedicineElsevier

Published: Mar 8, 2004

References

  • Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction
    Woodfield, S.L.; Lundergan, C.F.; Reiner, J.S.
  • Lipid management among coronary artery disease patients with diabetes mellitus or advanced age
    Massing, M.W.; Sueta, C.A.; Chowdhury, M.
  • Treatment of cardiac risk factors in diabetic patients
    George, P.B.; Tobin, K.J.; Corpus, R.A.
  • Geometric features of coronary artery lesions favoring acute occlusion and myocardial infarction
    Ledru, F.; Theroux, P.; Lesperance, J.
  • Diabetes and atherosclerosis
    Beckman, J.A.; Creager, M.A.; Libby, P.
  • New diagnostic criteria for diabetes and coronary artery disease
    Ledru, F.; Ducimetiere, P.; Battaglia, S.
  • Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery
    Kawano, H.; Motoyama, T.; Hirashima, O.
  • A self-fulfilling prophecy
    Verma, S.; Wang, C.H.; Li, S.H.
  • Prevalence of hyperinsulinaemia in patients with high blood pressure
    Zavaroni, I.; Mazza, S.; Dall'Aglio, E.
  • Is there a role for beta-blockers in hypertensive diabetic patients?
    Tse, W.Y.; Kendall, M.
  • Change of left ventricular geometric pattern after 1 year of antihypertensive treatment
    Wachtell, K.; Dahlof, B.; Rokkedal, J.

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