Considerations for Successful Treatment-free Remission in Chronic Myeloid Leukemia

Considerations for Successful Treatment-free Remission in Chronic Myeloid Leukemia BCR-ABL1 tyrosine kinase inhibitors have dramatically improved outcomes for patients with chronic myeloid leukemia, and current studies are investigating whether some patients may be able to suspend therapy yet maintain response in a state known as “treatment-free remission” (TFR). Results from ongoing studies suggest that ≈ 40% to 60% of patients in sustained (generally ≥ 2 years) deep molecular response (defined as a 4-log or deeper reduction in BCR-ABL1 transcripts, depending on the study) who attempt TFR may successfully remain off treatment. Results from TFR clinical trials, patient considerations for attempting TFR, and potential predictive factors associated with successful TFR are reviewed herein. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Lymphoma Myeloma and Leukemia Elsevier

Considerations for Successful Treatment-free Remission in Chronic Myeloid Leukemia

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Publisher
Elsevier
Copyright
Copyright © 2017 The Authors
ISSN
2152-2650
eISSN
2152-2669
D.O.I.
10.1016/j.clml.2017.11.006
Publisher site
See Article on Publisher Site

Abstract

BCR-ABL1 tyrosine kinase inhibitors have dramatically improved outcomes for patients with chronic myeloid leukemia, and current studies are investigating whether some patients may be able to suspend therapy yet maintain response in a state known as “treatment-free remission” (TFR). Results from ongoing studies suggest that ≈ 40% to 60% of patients in sustained (generally ≥ 2 years) deep molecular response (defined as a 4-log or deeper reduction in BCR-ABL1 transcripts, depending on the study) who attempt TFR may successfully remain off treatment. Results from TFR clinical trials, patient considerations for attempting TFR, and potential predictive factors associated with successful TFR are reviewed herein.

Journal

Clinical Lymphoma Myeloma and LeukemiaElsevier

Published: Feb 1, 2018

References

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