Conserved Features in Papillomavirus and Polyomavirus Capsids

Conserved Features in Papillomavirus and Polyomavirus Capsids Capsids of papilloma and polyoma viruses (papovavirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedral lattice (triangulation number of seven, T=7). Cottontail rabbit papillo mavirus (CRPV) was reported previously to be a T=7 laevo (left-handed) structure, whereas human wart virus, simian virus 40, and murine polyomavirus were shown to be T=7 dextro (right-handed). The CRPV structure determined by cryoelectron microscopy and image reconstruction was similar to previously determined structures of bovine papillomavirus type 1 (BPV-1) and human papillomavirus type 1 (HPV-1). CRPV capsids were observed in closed (compact) and open (swollen) forms. Both forms have star-shaped capsomeres, as do BPV-1 and HPV-1, but the open CRPV capsids are ≈2 nm larger in radius. The lattice hands of all papillomaviruses examined in this study were found to be T=7 dextro . In the region of maximum contact, papillomavirus capsomeres interact in a manner similar to that found in polyomaviruses. Although papilloma and polyoma viruses have differences in capsid size (≈60 versus ≈50 nm), capsomere morphology (11 to 12 nm star-shaped versus 8 nm barrel-shaped), and intercapsomere interactions (slightly different contacts between capsomeres), papovavirus capsids have a conserved, 72-pentamer, T=7 dextro structure. These features are conserved despite significant differences in amino acid sequences of the major capsid proteins. The conserved features may be a consequence of stable contacts that occur within capsomeres and flexible links that form among capsomeres. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Biology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1996 Academic Press
ISSN
0022-2836
DOI
10.1006/jmbi.1996.0317
Publisher site
See Article on Publisher Site

Abstract

Capsids of papilloma and polyoma viruses (papovavirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedral lattice (triangulation number of seven, T=7). Cottontail rabbit papillo mavirus (CRPV) was reported previously to be a T=7 laevo (left-handed) structure, whereas human wart virus, simian virus 40, and murine polyomavirus were shown to be T=7 dextro (right-handed). The CRPV structure determined by cryoelectron microscopy and image reconstruction was similar to previously determined structures of bovine papillomavirus type 1 (BPV-1) and human papillomavirus type 1 (HPV-1). CRPV capsids were observed in closed (compact) and open (swollen) forms. Both forms have star-shaped capsomeres, as do BPV-1 and HPV-1, but the open CRPV capsids are ≈2 nm larger in radius. The lattice hands of all papillomaviruses examined in this study were found to be T=7 dextro . In the region of maximum contact, papillomavirus capsomeres interact in a manner similar to that found in polyomaviruses. Although papilloma and polyoma viruses have differences in capsid size (≈60 versus ≈50 nm), capsomere morphology (11 to 12 nm star-shaped versus 8 nm barrel-shaped), and intercapsomere interactions (slightly different contacts between capsomeres), papovavirus capsids have a conserved, 72-pentamer, T=7 dextro structure. These features are conserved despite significant differences in amino acid sequences of the major capsid proteins. The conserved features may be a consequence of stable contacts that occur within capsomeres and flexible links that form among capsomeres.

Journal

Journal of Molecular BiologyElsevier

Published: Jun 7, 1996

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