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present variant Ph chromosomes involving 1 or more additional chromosomes , other than chromosomes 9 and 22 , with uncertain prognosis. There are mainly 1- or 2-step mechanisms proposed to explain the genesis ...
Microarray-based comparative genomic hybridization (array-CGH) led to the discovery of genetic abnormalities among patients with complex phenotype and normal karyotype. Also several apparently normal ...
Abstract BACKGROUND Complex chromosomal rearrangements (CCRs) describe structural rearrangements , essentially translocations, involving at least three breakpoints on two or more chromosomes . Although ...
chromosome pairing at the pachytene stage: these chromatid exchanges, in the case of complex meiotic configurations, increase the risk of chromosome rearrangement , as for patient II4‐A, and of segmental ...
-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients . We present data of the molecular characterization of 1590 MLL- rearranged biopsy samples obtained ...
22q11.2 deletions is not significantly different of that observed in patients with the common 3 Mb 22q11.2DS. We mapped the rearranged chromosome 22 in these six IBBC individuals to characterize those ...
alterations were present in isolation. Whole chromosome gains/losses were frequent, including gains +7 (n=13), +5 ( 9 ), +20 (8), +21 (8), +2 (8), +12 (7), +15 (6) and losses - 22 (14), -14 (8), -13 (6). Losses ...
known to be a driver of chromosomal rearrangements . Our study highlights an unprecedented level of polymorphism in the structure of LCR22s, which are likely still evolving. We present the most ...
and triplication of the distal 3 and 4 probes, as proposed by the array data above. D) FISH results for patient P113, depicting a quadruplication/duplication rearrangement of the region. High-resolution aCGH showed ...
Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately ...
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