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Comparison of frequency of new coronary events in older subjects with and without valvular aortic sclerosis

Older subjects with valvular aortic stenosis have a higher prevalence of coronary risk factors, 1–4 a higher prevalence of coronary artery disease (CAD), 3,5,6 and a higher incidence of new coronary events 6–8 than older subjects without valvular aortic stenosis. The early lesion of degenerative valvular aortic stenosis also has some similarities to atherosclerosis. 9 In a prospective study of 2,358 older subjects who had undergone continuous-wave Doppler echocardiography, 378 (16%) had valvular aortic stenosis, 981 (42%) had valvular aortic sclerosis, and 999 (42%) had no valvular aortic stenosis or sclerosis. We compare the frequency of new coronary events in these older subjects with valvular aortic sclerosis and with no valvular aortic stenosis or sclerosis. In a prospective study of 2,358 older subjects, valvular aortic stenosis was diagnosed by 2-dimensional and continuous-wave Doppler echocardiograms in 378 subjects (16%) as previously described. 6 These subjects with valvular aortic stenosis were excluded from the present study. The remaining 1,980 subjects included 625 men and 1,355 women (mean age 81 ± 8 years, range 60 to 103). Of these 1,980 subjects, 981 (50%) had valvular aortic sclerosis. Valvular aortic sclerosis was diagnosed if there was thickening of, or calcific deposits on, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Cardiology Elsevier
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