Article history: The present study aimed to evaluate the physical stability on amorphous solid dispersion (SD) of Received 29 August 2011 cyclosporine A (CsA) employing hydroxypropyl cellulose (HPC). SD formulations (5–30% CsA) of CsA such Received in revised form 8 December 2011 wet-milled SD (WM/SD) and freeze-dried SD (FD/SD) were prepared, and both SD formulations were Accepted 11 January 2012 stored at 40 C/75% relative humidity for 8 weeks. Transitions in morphology, dissolution behavior, crys- Available online 20 January 2012 tallinity and thermal behavior of CsA were evaluated. There was at least 84-fold improvement in initial dissolution rate of SD formulations compared with that of amorphous CsA powder, although their disso- Keywords: lution rate was gradually decreased under accelerated conditions. In particular, aged FD/SD with a drug Cyclosporine A load of 30% exhibited highly limited dissolution as evidenced by 40% reduction of solubility after 8 weeks Amorphous of storage. In contrast, aged WM/SD exhibited less reduction in dissolution rate compared with FD/SD. No Solid dispersion signiﬁcant changes were seen in crystallinity and thermal behavior after aging of SD formulations for 8 Solid solution Stability weeks; however, electron microscopic observations revealed aggregation of drug molecules/particles in the aged FD/SD, possibly
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera