10.1006/gcen.1999.7431

10.1006/gcen.1999.7431 General and Comparative Endocrinology 117, 427–438 (2000) doi:10.1006/gcen.1999.7431, available online at http://www.idealibrary.com on Comparative Aspects of the Metabolism and Excretion of Cortisol in Three Individual Nonhuman Primates1 N. I. Bahr, R. Palme,* U. Mohle, J. K. Hodges, and M. Heistermann2 ¨ Department of Reproductive Biology, German Primate Center, Kellnerweg 4, D-37077 Gottingen, Germany; ¨ and *Institute of Biochemistry and Ludwig Boltzmann Institute of Veterinary Endocrinology, University of Veterinary Medicine, Veterinarplatz 1, A-1210 Vienna, Austria ¨ Accepted November 24, 1999 A radiometabolism study is described to provide the first comparative data on the time course, route, and characteristics of excreted [3H]cortisol metabolites in three nonhuman primates: the common marmoset (Callithrix jacchus), the long-tailed macaque (Macaca fascicularis), and the chimpanzee (Pan troglodytes). A low dose (40–100 Ci) of 3H-labeled cortisol was administered intravenously to one adult male of each species and the excreta collected over a 5-day period postinjection. The major proportion of radioactivity was excreted in the urine (G80%). Peak radioactivity in urine was recovered within 5.5 h following injection in all three species, while in the feces peak levels of radioactivity were recovered within 26 h postinjection. In all three species, urinary metabolites were primarily excreted as conjugates http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

10.1006/gcen.1999.7431

Elsevier — Jun 11, 2020

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Abstract

General and Comparative Endocrinology 117, 427–438 (2000) doi:10.1006/gcen.1999.7431, available online at http://www.idealibrary.com on Comparative Aspects of the Metabolism and Excretion of Cortisol in Three Individual Nonhuman Primates1 N. I. Bahr, R. Palme,* U. Mohle, J. K. Hodges, and M. Heistermann2 ¨ Department of Reproductive Biology, German Primate Center, Kellnerweg 4, D-37077 Gottingen, Germany; ¨ and *Institute of Biochemistry and Ludwig Boltzmann Institute of Veterinary Endocrinology, University of Veterinary Medicine, Veterinarplatz 1, A-1210 Vienna, Austria ¨ Accepted November 24, 1999 A radiometabolism study is described to provide the first comparative data on the time course, route, and characteristics of excreted [3H]cortisol metabolites in three nonhuman primates: the common marmoset (Callithrix jacchus), the long-tailed macaque (Macaca fascicularis), and the chimpanzee (Pan troglodytes). A low dose (40–100 Ci) of 3H-labeled cortisol was administered intravenously to one adult male of each species and the excreta collected over a 5-day period postinjection. The major proportion of radioactivity was excreted in the urine (G80%). Peak radioactivity in urine was recovered within 5.5 h following injection in all three species, while in the feces peak levels of radioactivity were recovered within 26 h postinjection. In all three species, urinary metabolites were primarily excreted as conjugates

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