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with testolactone was effective therapy, and that more potent and specific inhibitors of aromatase could further improve the treatment of these disorders. ...
Combined antiandrogen (spironolactone) and aromatase inhibitor (testolactone) are effective for the short term treatment of familial male precocious puberty. During this therapy, plasma testosterone ...
/day), a moderately specific aromatase inhibitor (testolactone [TL], 220 mg/kg/day), or a highly specific aromatase inhibitor (fadrozole [FAD], 0.6 or 6.0 mg/kg/day). None of these treatments altered ...
, a combination of an aromatase inhibitor and antiandrogen has been used in the treatment of FMPP. A review of cases reported by Özcabı et al. demonstrated that combination therapy with anastrozole and bicalutamide ...
of continuous antiandrogen treatment can reverse hyperandrogenemia induced by LET. Similar effects of antiandrogens have been observed in women with PCOS, with chronic flutamide treatment decreasing both T and LH ...
and mitosis of spermatogonia (Carreau et al., 2003). It was found that treatment of bonnet monkeys (Macaca radiata) with a triazole-containing aromatase inhibitor related to letrozole blocked spermatid ...
unaffected by fenarimol (Fig. 2 c and d). Prochloraz caused a significant decrease in brain aromatase activity in males from the 0.3 mg/l treatment group (Fig. 2e). Fenarimol did not affect brain aromatase ...
in intact male rats compared with that of hydroxyflutamide ( antiandrogen ) and finasteride (5α-reductase inhibitor ), two major drugs used for androgen suppression treatment of BPH. In intact male rats, S-1 (5 ...
receptor antagonist as well as a potent aromatase inhibitor (Andersen et al., 2002). Furthermore, prochloraz was able to activate the Ah receptor (unpublished data). The purpose of this study was to further ...
within the 50-μg/l fadrozole treatment group (Fig. 1). Measurements of brain aromatase activity were not made in the 2- and 10-μg/l treatment groups. Fadrozole caused a concentration-dependent decrease ...
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