Collision induced unfolding of isolated proteins in the gas phase: past, present, and future

Collision induced unfolding of isolated proteins in the gas phase: past, present, and future •Collision induced unfolding (CIU) uses gas phase activation to probe biomolecules.•CIU can detect subtle changes in protein structure, stability or composition.•CIU can probe a wide range of biomolecules, from multiprotein complexes to biotherapeutics.•CIU has potential as a high throughput technique, differentiating states in seconds. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Chemical Biology Elsevier

Collision induced unfolding of isolated proteins in the gas phase: past, present, and future

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1367-5931
D.O.I.
10.1016/j.cbpa.2017.11.010
Publisher site
See Article on Publisher Site

Abstract

•Collision induced unfolding (CIU) uses gas phase activation to probe biomolecules.•CIU can detect subtle changes in protein structure, stability or composition.•CIU can probe a wide range of biomolecules, from multiprotein complexes to biotherapeutics.•CIU has potential as a high throughput technique, differentiating states in seconds.

Journal

Current Opinion in Chemical BiologyElsevier

Published: Feb 1, 2018

References

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