Cocaine- and amphetamine-regulated transcript (CART) peptide (CART-(55–102)) is involved in the suppression of food intake. We now report that CART-(55–102) is involved in anxiety in rodents. Intracerebroventricularly administered CART-(55–102) as well as intraperitoneal administration of N -methyl-β-carboline-3-carboxamide (FG-7142), a selective GABA A /benzodiazepine receptor inverse agonist, reduced time spent in the open arms in the elevated plus-maze task in mice. CART-(55–102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone. Likewise, CART-(55–102) and FG-7142 significantly reduced social interaction in mice. Both diazepam and buspirone significantly reversed CART-(55–102)-induced anxiogenic-like behavior in social interaction tests. By contrast, another biologically active CART peptide, CART-(62–102), was without effect in the elevated plus-maze task in mice. Moreover, intracerebroventricular administration of CART-(55–102) markedly increased the firing rate of locus coeruleus neurons in single unit recording in anesthetized rats. As CART-(55–102) produced anxiety-like effects in rodents, this peptide may possibly be involved in anxiety and stress-related behavior.
European Journal of Pharmacology – Elsevier
Published: Mar 7, 2003
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera