Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents

Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents Cocaine- and amphetamine-regulated transcript (CART) peptide (CART-(55–102)) is involved in the suppression of food intake. We now report that CART-(55–102) is involved in anxiety in rodents. Intracerebroventricularly administered CART-(55–102) as well as intraperitoneal administration of N -methyl-β-carboline-3-carboxamide (FG-7142), a selective GABA A /benzodiazepine receptor inverse agonist, reduced time spent in the open arms in the elevated plus-maze task in mice. CART-(55–102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone. Likewise, CART-(55–102) and FG-7142 significantly reduced social interaction in mice. Both diazepam and buspirone significantly reversed CART-(55–102)-induced anxiogenic-like behavior in social interaction tests. By contrast, another biologically active CART peptide, CART-(62–102), was without effect in the elevated plus-maze task in mice. Moreover, intracerebroventricular administration of CART-(55–102) markedly increased the firing rate of locus coeruleus neurons in single unit recording in anesthetized rats. As CART-(55–102) produced anxiety-like effects in rodents, this peptide may possibly be involved in anxiety and stress-related behavior. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(03)01368-2
Publisher site
See Article on Publisher Site

Abstract

Cocaine- and amphetamine-regulated transcript (CART) peptide (CART-(55–102)) is involved in the suppression of food intake. We now report that CART-(55–102) is involved in anxiety in rodents. Intracerebroventricularly administered CART-(55–102) as well as intraperitoneal administration of N -methyl-β-carboline-3-carboxamide (FG-7142), a selective GABA A /benzodiazepine receptor inverse agonist, reduced time spent in the open arms in the elevated plus-maze task in mice. CART-(55–102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone. Likewise, CART-(55–102) and FG-7142 significantly reduced social interaction in mice. Both diazepam and buspirone significantly reversed CART-(55–102)-induced anxiogenic-like behavior in social interaction tests. By contrast, another biologically active CART peptide, CART-(62–102), was without effect in the elevated plus-maze task in mice. Moreover, intracerebroventricular administration of CART-(55–102) markedly increased the firing rate of locus coeruleus neurons in single unit recording in anesthetized rats. As CART-(55–102) produced anxiety-like effects in rodents, this peptide may possibly be involved in anxiety and stress-related behavior.

Journal

European Journal of PharmacologyElsevier

Published: Mar 7, 2003

References

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