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, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are poorly soluble , which results in low bioavailability, diminished therapeutic effects, and dosage ...
AAPS PharmSciTech, Vol. 9, No. 2, June 2008 ( 2008) DOI: 10.1208/s12249-008-9057-5 Brief/Technical Note Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs : A Technical Note 1,2 1 ...
to specific properties such as their capacity to solubilize poorly water- soluble drugs , biocompatibility, and the ability to accumulate in tumor via enhanced permeability and retention (EPR). Moreover ...
solubility of silibinin and its targeted delivery to tumor. Revised: 7 Oct. 2019 Methods: Co -solvent evaporation method was used to incorporate silibinin into PEG-PCL based Accepted: 8 Oct. 2019 micelles . Drug ...
peripheries. A large number of poorly soluble hydrophobic drugs can be solubilized into the hydrophobic core and hence bioavailability of the drug ...
such as paclitaxel (PTX) are poorly soluble in water and therefore have to be solubilized for clinical applications. Amphiphilic block copolymers self‐assemble in aqueous solutions to yield polymeric micelles 1–7 ...
, however, the co -solvent partitioned out of the surfactant microstructure, leading to drug solubilization by independent micellization and co -solvency. This loss of excipient interaction caused formulation ...
) for the oral delivery of resveratrol. The micellar nanocarriers were designed to comprise a PCL core for solubilizing the poorly water- soluble drug and a hydrated PMAA corona with bioadhesive properties ...
Abstract This article proposes a new technique for the solubilization of poorly soluble drugs using lauroyl-L-glutamate, which is one of the amino acid detergents, with additional small additives ...
solubilization efficiency) and have been proven effective in the delivery of various poorly water- soluble drugs .[15,16] Contrary to the extensive studies on drug solubilization by block copolymer micelles over ...
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