Co-localization of 5-HT 2A -receptor- and GABA-immunoreactivity in neurones in the periaqueductal grey matter of the rat

Co-localization of 5-HT 2A -receptor- and GABA-immunoreactivity in neurones in the periaqueductal... The dorsal half of the midbrain periaqueductal grey matter (dPAG) functions as a midbrain aversive system. Serotonin exerts anti-aversive effects in the dPAG that are mediated by actions at 5-hydroxytryptamine (5-HT) 1A - and 5-HT 2A -receptors. Since at the cellular level, 5-HT 2A -receptor activation has been shown to evoke excitatory responses in the dPAG, it is possible that anti-aversive 5-HT 2A -mediated effects are mediated indirectly by activation of inhibitory gamma-aminobutyric acid (GABA)ergic interneurones. In rats, immunoreactivity for 5-HT 2A -receptors was present on the soma and dendrites of neurones throughout the PAG. Co-localization studies revealed that the majority (>90%) of 5-HT 2A -receptor-labelled cells also showed immunoreactivity for GABA. These findings may provide an anatomical substrate for 5-HT 2A -mediated anti-aversive effects in the dPAG. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Co-localization of 5-HT 2A -receptor- and GABA-immunoreactivity in neurones in the periaqueductal grey matter of the rat

Neuroscience Letters, Volume 326 (3) – Jul 5, 2002

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ireland Ltd
ISSN
0304-3940
DOI
10.1016/S0304-3940(02)00182-9
Publisher site
See Article on Publisher Site

Abstract

The dorsal half of the midbrain periaqueductal grey matter (dPAG) functions as a midbrain aversive system. Serotonin exerts anti-aversive effects in the dPAG that are mediated by actions at 5-hydroxytryptamine (5-HT) 1A - and 5-HT 2A -receptors. Since at the cellular level, 5-HT 2A -receptor activation has been shown to evoke excitatory responses in the dPAG, it is possible that anti-aversive 5-HT 2A -mediated effects are mediated indirectly by activation of inhibitory gamma-aminobutyric acid (GABA)ergic interneurones. In rats, immunoreactivity for 5-HT 2A -receptors was present on the soma and dendrites of neurones throughout the PAG. Co-localization studies revealed that the majority (>90%) of 5-HT 2A -receptor-labelled cells also showed immunoreactivity for GABA. These findings may provide an anatomical substrate for 5-HT 2A -mediated anti-aversive effects in the dPAG.

Journal

Neuroscience LettersElsevier

Published: Jul 5, 2002

References

  • Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area
    Doherty, M.D.; Pickel, V.
  • Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion
    Nogueira, R.L.; Graeff, F.G.

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