“Whoa! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Clinical Relevance of Pharmacokinetic Differences Between Beta Blockers

Clinical Relevance of Pharmacokinetic Differences Between Beta Blockers Fundamental differences in the pharmacodynamic and pharmacokinetic profiles of β-adrenergic blocking agents must be considered in optimizing their efficacy and determining the appropriate selection of these drugs in different patients. Beta blockers are contraindicated in patients with asthma and should be used cautiously in heart failure. Clinically important distinctions are related to whether a β blocker is β 1 -selective or nonselective. Most adverse effects of β-blocker use are related to interference with β 2 -mediated functions including bronchodilation, vasodilation, and mobilization of free fatty acids. To achieve the potential benefits of β 1 blockade (decreased heart rate, blood pressure, cardiac workload, and excitability), a low plasma concentration of a β 1 -selective drug is required. Adverse effects of β blockers can be further decreased by selecting a sustained-release β 1 -selective drug. Beta blockers are further differentiated on the basis of lipophilicity or hydrophilicity. Lipophilic β blockers cross the blood-brain barrier, whereas hydrophilic agents do not enter the central nervous system. Some lipophilic agents (metroprolol, timolol, and propanolol) have been shown to decrease mortality in coronary heart disease, particularly sudden cardiac death. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Cardiology Elsevier
Loading next page...
 
/lp/elsevier/clinical-relevance-of-pharmacokinetic-differences-between-beta-cKMxxo3r9K

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.