Classification of alcoholics on the basis of plasma β-endorphin concentration

Classification of alcoholics on the basis of plasma β-endorphin concentration Recent findings suggest that a genetic deficit in opioids may be a biological marker of alcoholism. In other words, decreased plasma concentrations of opioids may be a predisposing factor, rather than a consequence, of alcohol consumption. We attempted to classify 88 randomly chosen individuals as alcoholics or nonalcoholics on the basis of plasma concentration of β-endorphins. This criterion had a sensitivity of 73.30% and a specificity of 79.45%. Its positive predictive value was 42.30%, and its negative predictive value was 93.55%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcohol Elsevier

Classification of alcoholics on the basis of plasma β-endorphin concentration

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0741-8329
DOI
10.1016/0741-8329(95)00039-9
Publisher site
See Article on Publisher Site

Abstract

Recent findings suggest that a genetic deficit in opioids may be a biological marker of alcoholism. In other words, decreased plasma concentrations of opioids may be a predisposing factor, rather than a consequence, of alcohol consumption. We attempted to classify 88 randomly chosen individuals as alcoholics or nonalcoholics on the basis of plasma concentration of β-endorphins. This criterion had a sensitivity of 73.30% and a specificity of 79.45%. Its positive predictive value was 42.30%, and its negative predictive value was 93.55%.

Journal

AlcoholElsevier

Published: Nov 1, 1995

References

  • Behavioral and physiological effects of ethanol in high-risk and control children: a pilot study
    Bemar, D.; Berg, C.J.; Rapport, J.L.; Nelson, W.; Linnoila, M.; Cohen, M.; Buzevich, C; Marshall, T.
  • Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism
    Bosron, W.F.; Li, T.K.
  • Importance of delta opioid receptors in maintaining high alcohol drinking
    Froehlich, J.C.; Zweifel, M.; Harts, J.; Lumeng, L.; Li, T.K.
  • Asking the right questions
    Paton, A.; Saunders, J.B.
  • Methanol as a marker of alcohol abuse
    Roine, R.P.; Eriksson, C.J.; Ylikahari, R.; Penttilae, A.; Salaspuro, M.
  • Carbohydrate-deficient transferrin in serum: A new marker of potentially harmful alcohol consumption reviewed
    Stibler, H.

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