Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus

Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with... •Chemerin and leptin are increased, omentin-1 and visfatin are decreased in at term GDM-obese women.•Chemerin and omentin-1 are expressed mainly by the maternal VAT. Leptin is expressed mainly in maternal SAT.•Circulating chemerin and leptin in at term pregnancy correlate with BMI and HOMA-IR.•Chemerin and leptin could contribute to insulin resistance and low grade inflammation that characterizes GDM women complicated by obesity.•Weight control during pregnancy is necessary to avoid adverse metabolic complications for the mother and the offspring. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2018.01.005
Publisher site
See Article on Publisher Site

Abstract

•Chemerin and leptin are increased, omentin-1 and visfatin are decreased in at term GDM-obese women.•Chemerin and omentin-1 are expressed mainly by the maternal VAT. Leptin is expressed mainly in maternal SAT.•Circulating chemerin and leptin in at term pregnancy correlate with BMI and HOMA-IR.•Chemerin and leptin could contribute to insulin resistance and low grade inflammation that characterizes GDM women complicated by obesity.•Weight control during pregnancy is necessary to avoid adverse metabolic complications for the mother and the offspring.

Journal

PeptidesElsevier

Published: Mar 1, 2018

References

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