Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure

Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure •Blast-related traumatic brain injury (TBI) has been common in veterans of the recent conflicts in Iraq and Afghanistan.•Blast-related mild TBI (mTBI) has been frequently associated with post-traumatic stress disorder (PTSD).•Rats exposed to repetitive low-level blast develop PTSD-like behavioral traits in the absence of a psychological stressor.•The presence of such traits 28–35 weeks after blast exposure suggests that blast induces chronic behavioral effects.•These observations have implications for understanding the relationship of mTBI to PTSD in dual diagnosis veterans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2016.09.061
Publisher site
See Article on Publisher Site

Abstract

•Blast-related traumatic brain injury (TBI) has been common in veterans of the recent conflicts in Iraq and Afghanistan.•Blast-related mild TBI (mTBI) has been frequently associated with post-traumatic stress disorder (PTSD).•Rats exposed to repetitive low-level blast develop PTSD-like behavioral traits in the absence of a psychological stressor.•The presence of such traits 28–35 weeks after blast exposure suggests that blast induces chronic behavioral effects.•These observations have implications for understanding the relationship of mTBI to PTSD in dual diagnosis veterans.

Journal

Behavioural Brain ResearchElsevier

Published: Mar 15, 2018

References

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