Chronic imipramine enhances 5-HT 1A and 5-HT 2 receptors-mediated inhibition of panic-like behavior in the rat dorsal periaqueductal gray

Chronic imipramine enhances 5-HT 1A and 5-HT 2 receptors-mediated inhibition of panic-like... Electrical stimulation of the dorsal periaqueductal gray (DPAG) has been used to induce panic-like behavior in rats. In the present study, we investigated the effect of chronic imipramine treatment on the sensitivity of different 5-HT receptor subtypes in inhibiting aversion induced by electrical stimulation of this brain area. For that, the effects of intra-DPAG administration of the endogenous agonist 5-HT (20 nmol), the 5-HT 1A receptor agonist 8-OH-DPAT (8 nmol) and the 5-HT 2A/2C receptor agonist DOI (16 nmol) were measured in female Wistar rats given either chronic injection of imipramine (15 mg/kg, 3 weeks, ip) or saline. The results showed that the three receptor agonists raised the threshold of aversive electrical stimulation in both groups of animals, but this antiaversive effect was significantly higher in rats treated with imipramine. Treatment with imipramine did not change the basal threshold of aversive electrical stimulation measured before intra-DPAG injection of the 5-HT agonists. The results suggest that sensitization of both 5-HT 1A and 5-HT 2 receptors within the DPAG may be involved in the beneficial effect of imipramine in panic disorder (PD). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Chronic imipramine enhances 5-HT 1A and 5-HT 2 receptors-mediated inhibition of panic-like behavior in the rat dorsal periaqueductal gray

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/S0091-3057(01)00785-7
Publisher site
See Article on Publisher Site

Abstract

Electrical stimulation of the dorsal periaqueductal gray (DPAG) has been used to induce panic-like behavior in rats. In the present study, we investigated the effect of chronic imipramine treatment on the sensitivity of different 5-HT receptor subtypes in inhibiting aversion induced by electrical stimulation of this brain area. For that, the effects of intra-DPAG administration of the endogenous agonist 5-HT (20 nmol), the 5-HT 1A receptor agonist 8-OH-DPAT (8 nmol) and the 5-HT 2A/2C receptor agonist DOI (16 nmol) were measured in female Wistar rats given either chronic injection of imipramine (15 mg/kg, 3 weeks, ip) or saline. The results showed that the three receptor agonists raised the threshold of aversive electrical stimulation in both groups of animals, but this antiaversive effect was significantly higher in rats treated with imipramine. Treatment with imipramine did not change the basal threshold of aversive electrical stimulation measured before intra-DPAG injection of the 5-HT agonists. The results suggest that sensitization of both 5-HT 1A and 5-HT 2 receptors within the DPAG may be involved in the beneficial effect of imipramine in panic disorder (PD).

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Jul 1, 2002

References

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