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as FANCU) and XRCC3, are predisposed to breast, ovarian and prostate cancers1–10 and the cancer-prone syndrome Fanconi anaemia11–13. The BRCA2 tumour suppressor protein—the product of BRCA2 —is well ...
by the BRCA1 and BRCA2 breast cancer susceptibility genes, and other tumour suppressors — such as the Fanconi anaemia gene products — to cell-cycle checkpoint control and DNA repair by homologous recombination ...
in a cytoplasmic and nuclear network of genome stability and tumour suppressor pathways (Figure 7). FA proteins most probably play crucial roles in DNA repair, telomere stability , chromatin remodelling ...
to be required for the restart of stalled or broken replication forks. The RAD51 recombinase interacts directly with the breast cancer-associated tumour suppressor BRCA2 , an interaction that is required for normal ...
susceptibility proteins Brca1 and Brca2 (15–20). We recently identified a positional candidate for the We have been working towards the cloning of the gene defective XRCC2 DNA repair gene at human chromosome ...
Abstract Tumours with mutations in the BRCA1/ BRCA2 genes have impaired double-stranded DNA break repair, compromised replication fork protection and increased sensitivity to replication blocking ...
Abstract The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic ...
Introduction BRCA2 , PALB2, BRCA1, Rad51 and the Rad51 paralogs form the principal constituents of the homologous recombination (HR) machinery utilised by the cell not only to repair deleterious DNA ...
-inserted sequences (4). The epigenetic inactivation of tumour suppressor genes by DNA hypermethylation described in Figure 1 seems to be tumour -type specific (9) and affects all cellular pathways. Examples ...
as a tumour suppressor . Of all the functions associated with p53, it is likely that its primordial function is to monitor genome stability and maintain cellular homoeostasis (Junttila and Evan, 2009; Lu et al ...
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