Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Cell Biology Elsevier

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

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Abstract

The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

Journal

Current Opinion in Cell BiologyElsevier

Published: Jun 1, 2001

References

  • Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
    Sonoda, E.; Sasaki, M.S.; Buerstedde, J.M.; Bezzubova, O.; Shinohara, A.; Ogawa, H.; Takata, M.; Yamaguchi-Iwai, Y.; Takeda, S.
  • DNA double-strand breaks caused by replication arrest
    Michel, B.; Ehrlich, S.D.; Uzest, M.

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