•Chitosan-grafted pNIPAM copolymers with the thermo-responsive behavior were synthesized.•Degree of pNIPAM substitution on chitosan backbone affects the physical properties of the prepared polymers.•Drug loading efficiency of the nanogel formulations depends on the degree of pNIPAM substitution.•The nanogel formulations (with and without curcumin) are relatively safe.•CS-g-pN nanogels can deliver curcumin into tested cells and showed the dose-dependent cytotoxicity against cancer cells.
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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