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Measuring both progestagens , androgens, corticosteroids as well as estrogens with a single method makes it possible to investigate the effects of endocrine-disrupting chemicals (EDCs) on the main ...
, anti‐androgens, progestagens , etc. The effects (if any, of course) of such chemicals on aquatic organisms are unknown, and largely uninvestigated, presently. Much of the biological research has centred ...
Today, freshwaters, such as lakes and rivers, are subject to controlled pollution. Steroid hormones are chemically very stable highly lipophilic molecules. Their biological properties have a strong ...
, androgenic, or progestagenic materials. (EDTA, 2001; Kanno, 2003a,b). The role of estrogens in biological systems is complex; the ligand-inducible nuclear receptor-mediated action of this hormone results ...
and are used in combination with estrogen (E) usually ethinyl-estradiol (EE). The development of new generations of progestins with improved selectivity profiles has been a great challenge. Steroidal ...
measurement of 11 hormones, including progestagens , corticosteroids, androgens, and estrogens . To date, 2012 chemicals have been screened at 1 concentration; of these, 656 chemicals have been screened ...
fast analysis of the activities of new chemicals , food additives, and pharmaceutical compounds, high-throughput screening strategies have been developed. Here, a panel of mainly steroidal compounds ...
activation pathway in vitro. estrogen receptor, pyrethroid insecticides, reporter gene assay, yeast two-hybrid assay, competitive ligand-binding assay Several natural and synthetic chemicals that are widely ...
on biological systems. Xenoestrogens are chemicals that have direct or indirect estrogenic activity in living systems. Recent evidence suggests that chemicals acting as estrogens can produce adverse effects ...
]. Alternatively, oxidation and conjugation reactions of estrogens may generate metabolites that have distinct biologic activities, including altered hormonal properties; genotoxicity, through the formation ...
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