Checking the Biocompatibility of Plant-Derived Metallic Nanoparticles: Molecular Perspectives

Checking the Biocompatibility of Plant-Derived Metallic Nanoparticles: Molecular Perspectives Understanding the biocompatibility of metallic nanoparticles (MNPs) is pivotal for biomedical applications. The biocompatibility of plant-derived MNPs has been mostly attributed to capped plant molecules. This claim seems to be straightforward but lacks conclusive evidence. The capped phytochemicals and the metallic core might have decisive and individual roles in imparting the overall biocompatibility. Whether capped phytochemicals really make sense in diminishing the toxicity effect of the otherwise naked or metallic core needs further analysis. Here, we readdress the biocompatibility of plant-derived MNPs with references to contemporary cellular assays, different reactants for green synthesis, possible epigenetic involvement, and nanobiocompatibility at the molecular level. Finally, we discuss relevant in vivo studies and large-scale production issues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Biotechnology Elsevier

Checking the Biocompatibility of Plant-Derived Metallic Nanoparticles: Molecular Perspectives

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0167-7799
D.O.I.
10.1016/j.tibtech.2016.02.005
Publisher site
See Article on Publisher Site

Abstract

Understanding the biocompatibility of metallic nanoparticles (MNPs) is pivotal for biomedical applications. The biocompatibility of plant-derived MNPs has been mostly attributed to capped plant molecules. This claim seems to be straightforward but lacks conclusive evidence. The capped phytochemicals and the metallic core might have decisive and individual roles in imparting the overall biocompatibility. Whether capped phytochemicals really make sense in diminishing the toxicity effect of the otherwise naked or metallic core needs further analysis. Here, we readdress the biocompatibility of plant-derived MNPs with references to contemporary cellular assays, different reactants for green synthesis, possible epigenetic involvement, and nanobiocompatibility at the molecular level. Finally, we discuss relevant in vivo studies and large-scale production issues.

Journal

Trends in BiotechnologyElsevier

Published: Jun 1, 2016

References

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