Article history: In this study, we synthesized multicomponent solid ﬁlms of low-dose doxorubicin (DOX)-loaded poly- Received 14 March 2017 dimethylsiloxane (PDMS)-SiO /CaP nanocomposites via sol–gel process combined with the method of Received in revised form 19 July 2017 evaporation-induced self-assembly (EISA) at low temperature. Nanomechanical properties (elasticity and Accepted 1 August 2017 adhesion) of the synthesized multicomponent ﬁlms were determined by using atomic force microscopy Available online 5 August 2017 TM with a PeakForce quantitative nanomechanical mapping imaging technique. Solid state of DOX in the synthesized ﬁlms was studied by using UV–vis and ﬂuorescence spectroscopy. The release proﬁle of Keywords: different concentrations of DOX loaded (1, 3, and 5 wt%) on the multicomponent ﬁlms was assessed Nanoscale phase separation using USP Apparatus 4 and via UV–vis end analysis. Results indicate drug–component interactions on Polydimethylsiloxane/silica ﬁlms the overall morphology of domains (size and shape), nanomechanical properties, and release behavior Nanocomposites of the DOX-loaded nanocomposites. We observed a progressive increase in surface roughness and mean Low-dose drug-loaded ﬁlms Atomic force microscopy adhesive value with increasing concentration of DOX loaded (0–5 wt%). In addition, for all the different Evaporation-induced self-assembly concentrations of DOX-loaded, we observed a diffusion-controlled drug release. technique © 2017
Applied Surface Science – Elsevier
Published: Jan 1, 2018
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