Characterization of low-dose doxorubicin-loaded silica-based nanocomposites

Characterization of low-dose doxorubicin-loaded silica-based nanocomposites Article history: In this study, we synthesized multicomponent solid films of low-dose doxorubicin (DOX)-loaded poly- Received 14 March 2017 dimethylsiloxane (PDMS)-SiO /CaP nanocomposites via sol–gel process combined with the method of Received in revised form 19 July 2017 evaporation-induced self-assembly (EISA) at low temperature. Nanomechanical properties (elasticity and Accepted 1 August 2017 adhesion) of the synthesized multicomponent films were determined by using atomic force microscopy Available online 5 August 2017 TM with a PeakForce quantitative nanomechanical mapping imaging technique. Solid state of DOX in the synthesized films was studied by using UV–vis and fluorescence spectroscopy. The release profile of Keywords: different concentrations of DOX loaded (1, 3, and 5 wt%) on the multicomponent films was assessed Nanoscale phase separation using USP Apparatus 4 and via UV–vis end analysis. Results indicate drug–component interactions on Polydimethylsiloxane/silica films the overall morphology of domains (size and shape), nanomechanical properties, and release behavior Nanocomposites of the DOX-loaded nanocomposites. We observed a progressive increase in surface roughness and mean Low-dose drug-loaded films Atomic force microscopy adhesive value with increasing concentration of DOX loaded (0–5 wt%). In addition, for all the different Evaporation-induced self-assembly concentrations of DOX-loaded, we observed a diffusion-controlled drug release. technique © 2017 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Surface Science Elsevier

Characterization of low-dose doxorubicin-loaded silica-based nanocomposites

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0169-4332
eISSN
1873-5584
D.O.I.
10.1016/j.apsusc.2017.08.006
Publisher site
See Article on Publisher Site

Abstract

Article history: In this study, we synthesized multicomponent solid films of low-dose doxorubicin (DOX)-loaded poly- Received 14 March 2017 dimethylsiloxane (PDMS)-SiO /CaP nanocomposites via sol–gel process combined with the method of Received in revised form 19 July 2017 evaporation-induced self-assembly (EISA) at low temperature. Nanomechanical properties (elasticity and Accepted 1 August 2017 adhesion) of the synthesized multicomponent films were determined by using atomic force microscopy Available online 5 August 2017 TM with a PeakForce quantitative nanomechanical mapping imaging technique. Solid state of DOX in the synthesized films was studied by using UV–vis and fluorescence spectroscopy. The release profile of Keywords: different concentrations of DOX loaded (1, 3, and 5 wt%) on the multicomponent films was assessed Nanoscale phase separation using USP Apparatus 4 and via UV–vis end analysis. Results indicate drug–component interactions on Polydimethylsiloxane/silica films the overall morphology of domains (size and shape), nanomechanical properties, and release behavior Nanocomposites of the DOX-loaded nanocomposites. We observed a progressive increase in surface roughness and mean Low-dose drug-loaded films Atomic force microscopy adhesive value with increasing concentration of DOX loaded (0–5 wt%). In addition, for all the different Evaporation-induced self-assembly concentrations of DOX-loaded, we observed a diffusion-controlled drug release. technique © 2017

Journal

Applied Surface ScienceElsevier

Published: Jan 1, 2018

References

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